Giants vs. Pirates Prediction, Odds, Picks – August 6 Updated Aug. 6, 2025 12:00 p.m. ET sharefacebookxredditlink Data Skrive Oneil Cruz and the Pittsburgh Pirates will look to knock off Jung Hoo Lee and the San Francisco Giants on Wednesday at 12:35 p.m. ET at PNC Park. The Giants are the favorite in this one, at -152, while the underdog Pirates have +127 odds to win. San Francisco is the run-line favorite (-1.5). The total for the matchup is set at 8 runs. Here is everything you need from a betting perspective on the Giants-Pirates game, regarding the run line, moneyline and total, plus expert picks.Keep up with MLB on FOX Sports.Giants vs. Pirates Highlights | MLB on FOX Check out the best moments from this MLB matchup between the San Francisco Giants and the Pittsburgh Pirates. ADVERTISEMENT Giants vs. Pirates Game Information & OddsWhen: Wednesday, August 6, 2025 at 12:35 p.m. ETWhere: PNC Park in Pittsburgh, PennsylvaniaHow to watch on TV: SportsNet PT and NBCS-BA Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Giants -152 +127 8 -107 -113 -1.5 +111 -133 Giants vs. Pirates PredictionScore Prediction: Pirates 5, Giants 4Total Prediction: Over 8 runsWin Probabilities: Giants 51%, Pirates 49%Giants vs. Pirates Betting InsightsThis season, the Giants have won 35 out of the 68 games, or 51.5%, in which they’ve been favored.San Francisco has entered 32 games this season favored by -152 or more and is 16-16 in those contests.The moneyline for this contest implies a 60.3% chance of a victory for the Giants.The Pirates have won in 33, or 42.3%, of the 78 contests they have been named as odds-on underdogs this year.Pittsburgh has a mark of 13-29 in contests where oddsmakers favor it by +127 or worse on the moneyline.The Pirates have an implied victory probability of 44.1% according to the moneyline set by sportsbooks for this matchup.Giants Recent Betting PerformanceThe Giants went 1-5 across the six games they were a moneyline favorite in their last 10 matchups.Over their last 10 outings — all had a set run total — the Giants and their opponents combined to go over the total five times.The Giants’ record against the spread is 4-6-0 over their past 10 games. Giants Recent Stats Stat Avg/Total Record 3-7 Runs Per Game 4.5 HR 10 ERA 3.90 K/9 9.1 Giants Player InsightsRafael Devers is the Giants best power option, launching 20 home runs this season in addition to delivering 78 RBI, both team highs.Devers’ home runs place him 29th in MLB, and he is ninth in RBI.Lee is hitting .258 with 26 doubles, nine triples, six home runs and 38 walks.Lee ranks 228th in home runs and 104th in RBI among all MLB hitters this year.Lee has five straight games with at least one hit. During his last five outings he is batting .450 with four doubles, a triple, a walk and three RBIs.Willy Adames has 18 doubles, two triples, 18 home runs and 53 walks while hitting .232.Heliot Ramos has a club-high .275 batting average.Ramos has recorded at least one hit in six games in a row. During his last 10 outings he is hitting .325 with a double, seven walks and an RBI.Giants Team Props Hits O/U Total Bases O/U HR O/U RBI O/U Willy Adames 0.5 (-235) 1.5 (+110) – 0.5 (+150) Rafael Devers 0.5 (-240) 1.5 (+115) – 0.5 (+180) Matt Chapman 0.5 (-210) 1.5 (+115) – 0.5 (+145) Jung Hoo Lee 0.5 (-235) 1.5 (+125) – 0.5 (+210) Casey Schmitt 0.5 (-260) 1.5 (+115) – 0.5 (+165) Pirates Recent Betting PerformanceIn six games over the last 10 matchups when set as underdogs by sportsbooks, the Pirates had a record of 5-1.The Pirates and their opponents have combined to hit the over six times in their last 10 games with a total.The Pirates have a record of 7-3-0 ATS over their last 10 games. Pirates Recent Stats Stat Avg/Total Record 7-3 Runs Per Game 5.5 HR 13 ERA 4.85 K/9 9.0 Pirates Player InsightsCruz has put up a team-high 18 home runs.Among all batters in the majors, Cruz ranks 48th in home runs and 93rd in RBI.Bryan Reynolds has collected 53 runs batted in to lead his team.Among all major league hitters, Reynolds ranks 147th in home runs and 72nd in RBI.Andrew McCutchen has 16 doubles, 11 home runs and 41 walks while hitting .246.Isiah Kiner-Falefa paces the Pirates with a .271 batting average.Pirates Team Props Hits O/U Total Bases O/U HR O/U RBI O/U Tommy Pham 0.5 (-195) 1.5 (+135) – 0.5 (+230) Nick Gonzales 0.5 (-235) 1.5 (+120) – 0.5 (+165) Bryan Reynolds 0.5 (-190) 1.5 (+140) – 0.5 (+210) Oneil Cruz – – – – Henry Davis – – – – Giants vs. Pirates Highlights | MLB on FOX Check out the best moments from this MLB matchup between the San Francisco Giants and the Pittsburgh Pirates. 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